calorie restriction, longevity and cognitive function

Calorie Restriction, Longevity and Cognitive Function

Bile acids extend longevity beyond calorie restriction

discovery of potential anti-aging treatment capable of extending both our healthy aging and perhaps our longevity resuscitated an old human dream. It also brought about inordinate interest in these studies. While calorie restriction (CR) is still the best known intervention to increase life span, anti-aging molecules could mimic this effect without reducing nutrient intake. Such compounds, like...

The Implications of Calorie Restriction on Longevity and Health Span

Calorie Restriction (CR) is a defined intervention tool currently being studied as an effort to achieve numerous health benefits and increase longevity. Currently, there is a large body of research that indicates a multitude of health benefits and positive associations; however, there is also a plethora of opposing research. Through investigation of epigenetics, the efficacy of calorie restrict...

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

BACKGROUND NAD+ is a coenzyme for hydride transfer enzymes and a substrate for sirtuins and other NAD+-dependent ADPribose transfer enzymes. In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose limitation extends replicative lifespan in a manner that depends on Sir2 and the NAD+ salvage enzymes, nicotinic acid phosphoribosyl transferase and nicotinamidase. Though a...

Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity

Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with specific alterations in histone modifications that subsequently affect lifespan remains elusive. We show here that deletion of histone N-alpha-terminal acetyltransferase Nat4 ...